Semaphorin Signaling Unplugged
نویسندگان
چکیده
منابع مشابه
Semaphorin Signaling Unplugged A Nervy AKAP cAMP(s) Out on Plexin
was that high cyclic nucleotide levels favor attraction, Semaphorins signal through Plexin receptors to mediwhile low levels favor repulsion. Moreover, response ate a range of predominantly repulsive effects on axons conversion for some guidance cues is dependent on in the developing nervous system. Semaphorin-directed cAMP levels and extracellular calcium, while response repulsive turning resp...
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ble for the binding specificities of the semaphorins in situ (Feiner et al., 1997), while the Ig-basic domain also exhibits binding properties. The neuropilins have two N-terminal domains similar to complement binding domains , called CUB domains; two coagulation factor domains ; a C-terminal MAM domain; a transmembrane domain; and a short cytoplasmic tail (see figure). Both Giger et al. (1998)...
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Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for the formation of neuronal circuitry. Growth cones, the leading edges of axons, navigate by interacting with a variety of attractive and repulsive axon guidance cues along...
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Semaphorins play diverse roles in axon guidance and epithelial morphogenetic cell movements. In this issue of Genes & Development, Nukazuka and colleagues (1025-1036) show that semaphorins regulate Caenorhabditis elegans male tail morphogenesis by stimulating the translation of specific messages, including the actin-depolymerizing enzyme cofilin.
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Recent advances in our understanding of axon guidance during neural development are highlighted by the characterization of several gene families containing members capable of functioning as repellents. These include ephrins, netrins, and semaphorins. Though future work will undoubtedly result in the identification of still more repellents, the wealth of information now in hand concerning the ce...
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ژورنال
عنوان ژورنال: Neuron
سال: 2004
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(04)00258-2